Glycan-specific IgG anti-IgE autoantibodies are protective against allergic anaphylaxis in a murine model

BackgroundIgE causes anaphylaxis in type I hypersensitivity diseases by activating degranulation of effector cells such as mast and basophils. The mechanisms that control IgE activity prevent under normal conditions are still enigmatic.ObjectiveWe aimed to unravel how anti-IgE autoantibodies induced we understand their role regulating serum level allergic anaphylaxis.MethodsWe immunized mice with different forms tested autoantibody responses specificities. We then analyzed the effect those antibodies on kinetics vitro vivo impact anaphylaxis. Finally, investigated human sera.ResultsImmunization IgE-immune complexes glycan-specific autoantibodies. prevented cell sensitization, reduced total levels, protected from passive active resulted cross-protection against allergens. Furthermore, were present sera subjects allergy without allergy.ConclusionIn conclusion, this study provided first evidence murine model, anaphylactic may be downregulated IgG enigmatic. sera. Immunization allergy. In